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Distinct breakpoints in band 11q23 of the t(4;11) and t(11;14) associated with leukocyte malignancy

✍ Scribed by Paolo Radice; Dr. Alan Tunnacliffe

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
699 KB
Volume
5
Category
Article
ISSN
1045-2257

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✦ Synopsis

Several non-random translocation breakpoints associated with leukemia or lymphoma have been shown t o occur in chromosome band I I q23 between the genes CD3G and PBGD, a distance of approximately 750 kb. A combination of yeast artificial chromosome (YAC) cloning, in situ hybridization. and pulsed field gel electrophoresis (PFGE) experiments has further refined the interval containing one of these breakpoints, t(4;l l)(q2l;q23), to within 200 kb of CD3G. W e have extended the PFGE analysis to show that the t(4;l I ) breakpoint lies in a region of approximately 100 kb, situated 100 kb distal to CD3G. Furthermore, we show that a second I I q23 breakpoint, t( I I ; I4)(q23;q32). which was also previously mapped between CD3G and PBGD, is distinct from that of the t(4;l I) chromosome. The I I q23 sequences that are involved at the t( I 1;14) breakpoint are not present in a YAC containing the t(4; I I ) breakpoint. The t ( I I ; 14) breakpoint has been localized on the PFGE map of the CD3GPBGD interval and is at least I 10 kb distal to the t(4; I I) breakpoint, thus demonstrating heterogeneity among I lq23 breakpoints. Genes Chrorn Cancer 550-56 (1992). *) 1992 Wiley-Lirr, Inc.

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