The synthesis of ω-dialkylaminoalkylaminopyrazino[2,3-d]-, pyrido[2,3-d]-, imidazo[4,5-c]- and imidazo[4,5-d]pyridazines
✍ Scribed by Natu R. Patel; William M. Rich; Raymond N. Castle
- Book ID
- 112121685
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1968
- Tongue
- English
- Weight
- 988 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0022-152X
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Two synthetic routes to the versatile 3,5-dihydro-imidazo [4,5-d]pyridazin-4-ones 2 and 5 have been developed that allow the production of multigram quantities without the need of any chromatographic purification. Broad and selective elaboration of the heteroaromatic scaffolds has also been accompli
pyridazine derivatives 9a -d were synthesized by two pathways: thermal electrocyclic reaction of 3-alkenylimidazopyridine-2-oximes 10 and direct condensation of ethyl glycinate (or hydrazine) with 2,3-dicarbonylimidazo[1,2-a]pyridines 11.