Synthesis of 2-bromo-7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one and 3-alkyl-2-bromo-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one and their selective elaboration

✍ Scribed by Matthias Eckhardt; Norbert Hauel; Elke Langkopf; Frank Himmelsbach

• Publisher: Elsevier Science
• Year: 2008
• Tongue: French
• Weight: 113 KB
• Volume: 49
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2008.01.102

✦ Synopsis

Two synthetic routes to the versatile 3,5-dihydro-imidazo [4,5-d]pyridazin-4-ones 2 and 5 have been developed that allow the production of multigram quantities without the need of any chromatographic purification. Broad and selective elaboration of the heteroaromatic scaffolds has also been accomplished.