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The synthesis of β-lactams via a one-pot Reformatsky reaction of imines promoted by Zn/Cp2TiCl2 (cat.)

✍ Scribed by Lei Chen; Gang Zhao; Yu Ding

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
107 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

In the presence of Zn/Cp 2 TiCl 2 (cat.) a-bromoacetates, g-bromocrotonates or a-bromomethylacrylates react with imines in one-pot to form b-lactams, 3-vinyl-b-lactams or a-methylene-g-lactams, respectively, at room temperature without the need for pretreatment of the solvent and Zn.

📜 SIMILAR VOLUMES

Solvent-Free, One-Pot Synthesis of β-Lac
Solvent-Free, One-Pot Synthesis of β-Lactams by the Sc(OTf)3-Catalyzed Reaction of Silyl Ketene Thiocetals with Imines
✍ Maurizio Benaglia; Franco Cozzi; Alessandra Puglisi 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 105 KB

## Abstract A solvent‐free, catalytic, one‐pot synthesis of β‐lactams is described. The reaction involves the reaction between silyl ketene thioacetals derived from 2‐pyridyl thioesters and imines at room temperature in the presence of catalytic amounts of Sc(OTf)~3~ and in the absence of solvent.

Solvent-Free, One-Pot Synthesis of β-Lac
Solvent-Free, One-Pot Synthesis of β-Lactams by the Sc(O-Tf)3-Catalyzed Reaction of Silyl Ketene Thioacetals with Imines.
✍ Maurizio Benaglia; Franco Cozzi; Alessandra Puglisi 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 27 KB 👁 1 views

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