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The Synthesis of β-Lactams via a One-Pot Reformatsky Reaction of Imines Promoted by Zn/Cp2TiCl2 (cat.).

✍ Scribed by Lei Chen; Gang Zhao; Yu Ding


Publisher
John Wiley and Sons
Year
2003
Weight
202 KB
Volume
34
Category
Article
ISSN
0931-7597

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Solvent-Free, One-Pot Synthesis of β-Lac
✍ Maurizio Benaglia; Franco Cozzi; Alessandra Puglisi 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 105 KB

## Abstract A solvent‐free, catalytic, one‐pot synthesis of β‐lactams is described. The reaction involves the reaction between silyl ketene thioacetals derived from 2‐pyridyl thioesters and imines at room temperature in the presence of catalytic amounts of Sc(OTf)~3~ and in the absence of solvent.