The Synthesis of β-Lactams via a One-Pot Reformatsky Reaction of Imines Promoted by Zn/Cp2TiCl2 (cat.).
✍ Scribed by Lei Chen; Gang Zhao; Yu Ding
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 202 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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## Abstract A solvent‐free, catalytic, one‐pot synthesis of β‐lactams is described. The reaction involves the reaction between silyl ketene thioacetals derived from 2‐pyridyl thioesters and imines at room temperature in the presence of catalytic amounts of Sc(OTf)~3~ and in the absence of solvent.
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