✦ LIBER ✦

Solvent-Free, One-Pot Synthesis of β-Lactams by the Sc(OTf)3-Catalyzed Reaction of Silyl Ketene Thiocetals with Imines

✍ Scribed by Maurizio Benaglia; Franco Cozzi; Alessandra Puglisi

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 105 KB
Volume: 2007
Category: Article
ISSN: 1434-193X
DOI: 10.1002/ejoc.200601127

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A solvent‐free, catalytic, one‐pot synthesis of β‐lactams is described. The reaction involves the reaction between silyl ketene thioacetals derived from 2‐pyridyl thioesters and imines at room temperature in the presence of catalytic amounts of Sc(OTf)~3~ and in the absence of solvent. Extension of this procedure to the synthesis of an enantiomerically pure azetidinone, a precursor of industrially relevant bioactive β‐lactams, is also reported. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)

📜 SIMILAR VOLUMES

Solvent-Free, One-Pot Synthesis of β-Lac

Solvent-Free, One-Pot Synthesis of β-Lactams by the Sc(O-Tf)3-Catalyzed Reaction of Silyl Ketene Thioacetals with Imines.

✍ Maurizio Benaglia; Franco Cozzi; Alessandra Puglisi 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 27 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

ChemInform Abstract: Yb(OTf)3-Catalyzed

ChemInform Abstract: Yb(OTf)3-Catalyzed One-Pot Synthesis of β-Lactams from Silyl Ketene Thioacetals by a Two- or a Three-Component Reaction.

✍ R. ANNUNZIATA; M. CINQUINI; F. COZZI; V. MOLTENI; O. SCHUPP 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 37 KB 👁 1 views

Highly Diastereoselective Synthesis of β

Highly Diastereoselective Synthesis of β-Carboxy-γ-lactams and Their Ethyl Esters via Sc(OTf)3-Catalyzed Imino Mukaiyama-Aldol Type Reaction of 2,5-Bis(trimethylsilyloxy)furan with Imines.

✍ Manat Pohmakotr; Nattawut Yotapan; Patoomratana Tuchinda; Chutima Kuhakarn; Vich 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 30 KB 👁 1 views

ChemInform Abstract: Efficient One-Pot S

ChemInform Abstract: Efficient One-Pot Synthesis of β-Hydroxyphosphonates: Regioselective Nucleophilic Ring Opening Reaction of Epoxides with Triethyl Phosphite Catalyzed by Al(OTf)3.

✍ Sara Sobhani; Asieh Vafaee 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 23 KB 👁 1 views

ChemInform Abstract: One-Pot Synthesis o

ChemInform Abstract: One-Pot Synthesis of γ-Lactams in a Reaction Cascade from α,β-Unsaturated Imines, CO and Ethylene Catalyzed by Ru3(CO)12.

✍ Daniel Berger; Wolfgang Imhof 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB 👁 1 views

One-Pot Synthesis of 3,4-Dihydropyrimidi

One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones/-thiones Catalyzed by Zinc Chloride: An Improved Procedure for the Biginelli Reaction Using Microwaves under Solvent-Free Condition.

✍ M. A. Pasha; N. Ramachandra Swamy; V. P. Jayashankara 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 23 KB 👁 2 views