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The synthesis of well-defined heparin and heparan sulfate fragments

✍ Scribed by Jeroen D.C. Codée; Herman S. Overkleeft; Gijsbert A. van der Marel; Constant A.A. van Boeckel

Book ID
119226284
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
696 KB
Volume
1
Category
Article
ISSN
1740-6749

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Heparin stimulates 2-3-fold, in a concentration-dependent manner, the synthesis of heparan sulfate secreted by cultured endothelial cells. The increase in synthetic rate takes place immediately after exposure of the cells to heparin, affects only heparan sulfate, and i s specific for the endothelial