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The synthesis of two 14C-labelled hypoglycemic benzenesulphonylurea derivatives

✍ Scribed by L. F. Elsom; D. R. Hawkins; H. Christensen; F. C. Grønvald

Publisher
John Wiley and Sons
Year
1977
Tongue
French
Weight
519 KB
Volume
13
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of two carbon‐14 labelled oral hypoglycemic benzo(b)furansulphonylureas is deseribed. The starting materials 2,3 ‐dihydrobenzo (b)furan ‐7 ‐carboxylic acid and 5 methyl–2, 3‐dihydrobenzo (b)furan‐7‐^14^C‐carboxylic acid were prepared in high yield by carbonation of appropriate Grignard reagents. The final products were obtained with specific activities of 49 and 44 mCi/mmole and radiochemical purities of greater than 99%.

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