✦ LIBER ✦

Synthesis of 14C-labeled 7α-methoxycephalosporin derivative (14C-cefotetan)

✍ Scribed by Kazuharu Tamazawa; Hideki Arima

Publisher: John Wiley and Sons
Year: 1982
Tongue: French
Weight: 295 KB
Volume: 19
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580190508

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✦ Synopsis

Abstract

[Caboxamido‐^14^C]Cefotetan, 7α‐[4‐(carbamoyl carboxymethylene)‐1,3‐dithietan‐2‐yl] [^14^C]carboxamido‐7α‐methoxy‐3‐(1‐methyl‐1H‐tetrazol‐5‐yl)thiomethyl‐y1)thiomethyl‐3‐cephem‐4‐carboxylic acid (IX), a new cephamycin derivative, was synthesized from bromo[1‐^14^C]acetic acid for metabolic studies. The results of duplicate preparation of ^14^C‐Cefotetan are described. In the second synthesis, a new improved method was adopted. The overall radiochemical yields were 21.5 % and 26.7 %, at specific activity of 44.5 μCi/mg and 53.3 μCi/mg respectively.

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