THE SYNTHESIS OF TOLUENE-1,3,5-C 14 AND OXALIC ACID-C 14 ; THE MECHANISMS OF THE REACTIONS 1
β Scribed by HUGHES, DOROTHY M.; REID, JAMES C.
- Book ID
- 121183870
- Publisher
- American Chemical Society
- Year
- 1949
- Tongue
- English
- Weight
- 581 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0022-3263
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Specifically labelled phenylacetic acid and mandelic acid derivatives, metabolites of L-Dopa, have been synthesized via the intermediary labelled benzyl alcohols, which were prepared by reduction of the methyl esters of the appropriate benzoic acids. The benzyl alcohols have been converted to the co
## Abstract Existing methods have been adapted for the small scale synthesis of the title compounds in high yield. Modification of the iodoform reaction enables 1,3β^14^Cβacetone (I) to be converted in over 95% yield to ^14^Cβiodoform (II) which is reduced by sodium aresenite to ^14^Cβmethylene dii