The synthesis of the Sp and Rp diastereomers of dithymidine boranophosphate
โ Scribed by Yi Jin; George Just
- Book ID
- 104259766
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 173 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
The diastereomers of thymidyl-(3'-5')thymidyl O,O-boranophosphate Sp-4 and Rp-4 were easily separated and transformed to title compounds Sp-7 and Rp-7. Their configurations were assigned by comparison with literature data.
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The use of phosphorothioates as DNA analogues useful in antisense-based therapy is well established and led to the development of Vitravene as the first antisense drug. Several other phosphorothioate oligonucleotides (PS-Oligos) are in clinical trials. Although Stec et al. described an elegant oxa
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