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ChemInform Abstract: The Synthesis of the Sp and Rp Diastereomers of Dithymidine Boranophosphate.

โœ Scribed by Y. JIN; G. JUST

Publisher
John Wiley and Sons
Year
2010
Weight
22 KB
Volume
29
Category
Article
ISSN
0931-7597

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Stereoselective Synthesis of RP- and SP-
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The use of phosphorothioates as DNA analogues useful in antisense-based therapy is well established [1] and led to the development of Vitravene as the first antisense drug. [2] Several other phosphorothioate oligonucleotides (PS-Oligos) are in clinical trials. Although Stec et al. described an elega