The synthesis of steroidal [16α,17α-d]-2'-pyrazolines and [16,17-d]-pyrazoles
✍ Scribed by B. Green; B.L. Jensen; P.L. Lalan
- Publisher
- Elsevier Science
- Year
- 1978
- Tongue
- French
- Weight
- 759 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0040-4020
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📜 SIMILAR VOLUMES
BY oxidation of lt~-methylpregna-3,16-dien-38-ol-2O-one acetate' with hydrogen peroxide in alkaline methanolic solution we have prepared [a], -21' (Found: C, 76.58;
We have discovered that chlorine in 3~-acetoxy-17-chloro-16-formylandrosta-5,16-diene (1) can be smoothly displaced by nitrogen heterocyclic nucleophiles (her) to give heretofore unknown 17-substituted-A t6 steroids in high yields (73-92%). This enabled us to synthesize novel 3~-hydroxy-17-(1H-1,2,4
## Abstract The preparation of ^14^C‐labelled 11β, 21‐dihydroxy‐3,20‐dioxy‐pregna‐1,4‐dieno[ 17α, 16α‐d]‐2′‐methyloxazoline‐21‐acetate and of 9α‐fluoro‐11β,21‐dihydroxy‐3,20‐dioxopregna‐l,4‐dieno[ 17α,16α ]‐2′‐methyloxazoline‐21‐acetatelNote that [17α., 160α‐d] does not refer to deuterium labelling