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The Synthesis of Spiro[tetrahydroisoquinoline-piperidines] and related compounds

✍ Scribed by Daniel Berney; Theodor Jauner

Publisher
John Wiley and Sons
Year
1975
Tongue
German
Weight
372 KB
Volume
58
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

The reaction of 3,4‐dimethoxyphenethylamine with some cyclic aminoketones in the presence of polyphosphoric acid afforded 1‐spiro‐tetrahydroisoquinolines. A two‐step procedure starting from veratrylamine and amino‐ketones gave 3‐spiro‐tetrahydroisoquinolin‐4‐ones. The Schmidt rearrangement of 5,6‐dimethoxy‐3‐spiro‐indan‐1‐ones yielded 4‐spiro‐tetrahydroisoquinolin‐1‐ones.

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