## Abstract The reaction of 3,4‐dimethoxyphenethylamine with some cyclic aminoketones in the presence of polyphosphoric acid afforded 1‐spiro‐tetrahydroisoquinolines. A two‐step procedure starting from veratrylamine and amino‐ketones gave 3‐spiro‐tetrahydroisoquinolin‐4‐ones. The __Schmidt__ rearra
Kinetics of N-Formylation of Piperidine and Related Compounds
✍ Scribed by L. Maat; M. Peereboom
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2010
- Weight
- 146 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0037-9646
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✦ Synopsis
The kinetics of the N-formylation of piperidine and 3-methylpiperidine with chloral hydrate and 1,2,3,4-tetrahydroisoquinoline with chloral in toluene, have been investigated. The reactions are first order in both reactants. The formylation of piperidine is faster than that of I ,2,3,4-tetrahydroisoquinoline and somewhat slower than that of 3-methylpiperidine.
📜 SIMILAR VOLUMES
## Abstract The ^13^C NMR spectra of a series of methyl substituted 3‐arylpiperidines and 4‐aryl‐4‐piperidinols and related compounds are reported, and chemical shift data analysed in terms of the configuration and conformation of isomeric pairs. Special attention is given to the γ chemical shift p
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