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The Synthesis of Some Substituted Pyrimido[4,5-d]dihydropyrimidines 1

✍ Scribed by Dymicky, Michael; Caldwell, William T.

Book ID: 121084490
Publisher: American Chemical Society
Year: 1962
Tongue: English
Weight: 639 KB
Volume: 27
Category: Article
ISSN: 0022-3263
DOI: 10.1021/jo01059a020

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## Abstract Ethyl 1‐ethyl‐7‐methyl‐4‐oxo‐1,4‐dihydro[1,8]naphthyridine‐3‐carboxylate (**1**), precursor of nalidixic acid, has been converted in two steps through ([1,8]naphthyridin‐3‐yl)carbonylguanidine derivatives into substituted pyrimido[4,5‐__b__] and [5,4‐__c__][1,8]naphthyridines.