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The synthesis of some 3-acylindoles revisited

✍ Scribed by Vedran Hasimbegovic; Johnny Slätt; Jan Bergman; Tomasz Janosik

Publisher
Journal of Heterocyclic Chemistry
Year
2007
Tongue
English
Weight
285 KB
Volume
44
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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A study probing the scope of acylation of indoles with dicarboxylic acids in acetic anhydride has been performed, resulting in products incorporating 3‐acylindole‐ or 1‐acylindole motifs depending on the choice of the acid reactant. Synthetically useful results were only obtained from reactions involving malonic acid or Meldrum's acid. Correlations to previous studies have also been made and discussed.

📜 SIMILAR VOLUMES

Synthesis of 2-acylindole-3-acetic acids
Synthesis of 2-acylindole-3-acetic acids: a novel base-mediated indole synthesis
✍ Kazunari Nakao; Yoshinori Murata; Hiroki Koike; Chikara Uchida; Kiyoshi Kawamura 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 93 KB

An efficient and expedient synthetic route to 2-acylindole-3-acetic acids is described. This work first demonstrates a one-pot room-temperature indole ring construction via the in situ generation of indoline intermediate.