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The synthesis of some 2,4-disubstituted derivatives of quinolone-3-carboxylic acids and carbonitriles

โœ Scribed by D. L. Leysen; A. Haemers; W. Bollaert; R. A. Dommisse; E. L. Esmans


Book ID
112128754
Publisher
Journal of Heterocyclic Chemistry
Year
1987
Tongue
English
Weight
351 KB
Volume
24
Category
Article
ISSN
0022-152X

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## Abstract A modification of the Gouldโ€Jacobs reaction, particularly useful for the preparation of Nโ€alkylโ€4โ€quinoloneโ€3โ€carboxylic acids, is described. Decarboxylation of these acids leads to Nโ€alkylโ€4โ€quinolones or, in the case of Nโ€ethylโ€benzo[h]โ€4โ€quinoloneโ€3โ€carboxylic acid, to 4โ€ethoxyโ€benzo