✦ LIBER ✦

The synthesis of o- and p-[18F]fluorobenzyl bromides and their application to the prepatation of labeled neuroleptics

✍ Scribed by Kentaro Hatano; Tatsuo Ido; Ren Iwata

Publisher: John Wiley and Sons
Year: 1991
Tongue: French
Weight: 412 KB
Volume: 29
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580290403

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✦ Synopsis

Abstract

The syntheses of o‐ and p‐ [^18^F]fluorobenzyl bromides as labeled synthons were described. They were obtained from nitrobenzaldehyde via a three step synthesis that exhibited good yield. The preparation of [^18^F]fluororinated analog of a benzamide neuroleptic, cis‐N‐[(2RS, 3RS)‐1‐[^18^F]fluorobenzyl‐2‐methylpyrrolidin‐3‐yl] ‐5‐chloro‐2‐methoxy‐4‐methylaminobenzamide, via N‐benzylation with the synthons was also mentioned.

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