Application of the nucleophilic substitution reaction to the synthesis of No-carrier-added [18F]fluorobenzene and other 18F-labeled aryl fluorides
✍ Scribed by C.-Y. Shiue; M. Watanabe; A. P. Wolf; J. S. Fowler; P. Salvadori
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- French
- Weight
- 526 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0022-2135
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## Abstract The availability of no‐carrier‐added (n.c.a.) 1‐bromo‐4‐[^18^F]fluorobenzene with high radiochemical yields is important for ^18^F‐arylation reactions using metallo‐organic 4‐[^18^F]fluorophenyl compounds (e.g. of lithium or magnesium) or Pd‐catalyzed coupling. In this study, different
## Abstract The syntheses of o‐ and p‐ [^18^F]fluorobenzyl bromides as labeled synthons were described. They were obtained from nitrobenzaldehyde __via__ a three step synthesis that exhibited good yield. The preparation of [^18^F]fluororinated analog of a benzamide neuroleptic, __cis__‐N‐[(2RS, 3RS