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THE SYNTHESIS OF MALONYL-C 14 COENZYME A

✍ Scribed by Trams, E. G.; Brady, R. O.


Book ID
127069641
Publisher
American Chemical Society
Year
1960
Tongue
English
Weight
261 KB
Volume
82
Category
Article
ISSN
0002-7863

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A method for the synthesis of [14C]malonyl-Coenzyme A starting with 10 mumol of [14C]malonate is reported. The synthesis is accomplished with yields of 48 +/- 4% (1 sigma, n = 6) using a procedure which does not require the isolation or purification of any intermediates.

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## Abstract Radio‐labelled coenzyme Q~10~, labelled at the 3′‐position with ^14^C, was synthesized starting from natural solanesol and ethyl [3‐^14^C] acetoacetate. The radiochemical yield was 8.0% from ethyl [3‐^14^C] acetoacetate. The specific radioactivity of the product was 44.8 ΞΌCi, 1.66 MBq/m