## Actor. A sleazy general synthesis of methyl 2,4,~~xyJI\_a-~~~p~oside (lb), the thio sugar isolated from esperamicin, is described. 'I%e synthesis involves the neighbori& group assisted
The synthesis of derivatives of 4-amino-3-O- methyl-2,4,6-trideoxy-α-D-ribo-hexopyranose, a component of the steroidal alkaloid holacurtin.
✍ Scribed by J. Hildesheim; S.D. Géro; G. Khuong-Huu; C. Monneret
- Publisher
- Elsevier Science
- Year
- 1969
- Tongue
- French
- Weight
- 167 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0040-4039
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## Abstract The 4‐thio analog of 2,6‐dideoxy‐D‐__ribo__‐hexopyranose (D‐digitoxose) is part of the saccharide chain of the calicheamicins and esperamicins. A straightforward synthesis of the 4‐thiodigitoxoside 12 as its diacetate 13 starting from methyl α‐D‐galactopyranoside (1) is described. Prope
The conformational difference of the title compound (1) in the solid state and in solution has been investigated by X-ray crystallography and high-field proton n.m.r. spectrometry. In the solid state, compound 1 adopts the "c,(D) conformation (la), whereas 1 exists preferentially in the 'C4(D) confo