The Synthesis of Certain Sulfur-35 Labeled Sulfa Drugs†
✍ Scribed by Byrne, P.J. ;Alberts, A.A. ;Christian, J.E.
- Publisher
- Elsevier
- Year
- 1953
- Weight
- 276 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0095-9553
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## Abstract Two ^35^S reagents were developed to radiolabel proteins. The first reagent, a __N__‐hydroxysuccinimide (NHS) ester (SMSB), acylates the ε‐amino group of lysine residues in proteins. The second reagent, an aldehyde (MSAPPA), labels lysine residues via reductive alkylation. Comparing the
## Abstract Preparation of the title compound, tracer substances required for the development of the fasciollide clorsulon, is described. The ring‐u‐^14^C variety was obtained in 42.2% yield overall from purchased [ring‐u‐^14^C]acetophenone.
## Abstract Two new ^35^S reagents were developed to radiolabel proteins. The first reagent, __N__‐succinimidyl‐4‐(methane [^35^S]sulfonylamino‐methyl)‐benzoate (SMSB), acylates the ε‐amino group of lysine residues in proteins. The second reagent, 4‐(methane [^35^S]sulfonylamino‐methyl)‐phenylpropy