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The Synthesis of Carboxylic Acids via an Aldol-Grob Reaction Sequence

✍ Scribed by Kabalka, G. W.; Li, N.-S.; Tejedor, D.; Malladi, R. R.; Gao, X.; Trotman, S.


Book ID
118020142
Publisher
Taylor and Francis Group
Year
1999
Tongue
English
Weight
189 KB
Volume
29
Category
Article
ISSN
0039-7911

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The aldol reactions of ct-diazo-13-ketoesters with a variety of aldehydes produced adducts which underwent Rh(II)-catalyzed O-H insertion reaction to yield highly substituted tetrahydrofurans. Alkylation and decarboxylation of these tetrahydrofurans formed a wide