## Abstract As asymmetric route to [^14^C]β‐hydroxycompactin 1 bearing the (__S__)‐2‐methyl‐[1‐^14^C]butanoate side chain has been developed. Methylation of [N‐[1‐^14^C]butyryl‐4‐(__S__)‐phenylmethyl‐2‐oxazolidinone 4 afforded a 95:5 mixture of diastereomeric [N‐(__S,R__)‐2‐methyl‐[1‐^14^C]butyryl]
The Synthesis of Carbon-14 Labeled Chloroform†
✍ Scribed by Reitz, Henry C. ;Carleton, Frederick J. ;Christian, John E.
- Publisher
- Elsevier
- Year
- 1953
- Weight
- 252 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0095-9553
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✦ Synopsis
the official ointments used as controls in both ease of mixing and in the stability of the medicated ointments.
The rates of diffusion of iodine, sulfathiazole, and a mixture of benzoic and salicylic acids from the six silicone bases were compared with each other and with the rates of diffusion from three U. S. P. ointments. Silicone Gibson base showed the greatest rate of iodine diffusion, and hydrophilic ointment U. S. P., silicone glyceryl monostearate base, silicone anhydrous base, silicone hydrophilic ointment, silicone cold cream, silicone absorption base, hydrophilic petrolatum U. S. P., and white ointment U. S. P. followed in that order. The diffusion of sulfathiazole from silicone absorption base, white ointment U. S. P., and hydrophilic petrolatum U. S. P. was too slight $6 JOURNAL OF THE AMEFS&N PHAR~~ACEUTICAL ASSOCIATION Vol. XLII, NO. 2 C*H3CH0 + CH3C*H0 + 3Ca(OC1)2 -C*HCL + '/ZCa(HCOO)z CHCl, + 2Ca(OH)z + '/zCa(HC*OOh + ' obtained with the nonradioactive syntheses.
📜 SIMILAR VOLUMES
This report describes the synthesis of carbon-14 labeled title compound from [14C]CS2. The substituted benzimidazole was labeled at the C-2 position of the benzimidazole moiety.
## Abstract Carbon‐14 labeled vigabatrin was synthesized in 5 steps from 5‐hydroxymethyl‐2‐pyrrolidone tosylate and NaCN‐[^14^C]. A key step involved reduction of the resulting nitrile in the presence of excess dimethylamine to give the dimethylamino‐ethyl 2‐pyrrolidone derivative in one step. This
The synthesis and purification of carbon-14 labeled capsaicin are described.
Clomiphene, 2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy~-N.N- diethylethanamine, an antiestrogen, is a nonsteroidal triphenylethylene derivative. For the successful synthesis of carbon-14 labeled clomiphene it is essential to have a free radical inhibitor in the reaction medium.