𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The synthesis of alternative diketopiperazines as potential RGD mimetics

✍ Scribed by Nikolett Mihala; Antal Csámpai; Janez Ilaš; Danijel Kikelj; Robert Kiss; Helga Süli-Vargha


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
216 KB
Volume
12
Category
Article
ISSN
1075-2617

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Synthesis of RGD Analogs as Potential Ve
✍ Ji Jiang; Wei Wang; David C. Sane; Binghe Wang 📂 Article 📅 2001 🏛 Elsevier Science 🌐 English ⚖ 232 KB

RGD analogs bind to integrin receptors with high affinity and therefore have the potential to be used as vectors for the targeted delivery of pharmaceutical agents to designated sites. Critical to this application is the ability to synthesize RGD analogs with different side chain functional groups t

Synthesis of RGD analogues containing α-
✍ Alma Dal Pozzo; Laura Muzi; Maurizio Moroni; Riccardo Rondanin; Roberto de Casti 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 555 KB

AIImraet The ~ of two ~ mimetics of RGD, ct-Tfm-Arg-Gly-Asp-Phe-NHz 9 anti ct-Tfm-Arg431y-Asp-NH-(CH2h-C6Hs 13, is desmb~ The precursor of ct-Tfin-omithine was obtained in two s~ steps from 2-N-C~-2-T[m-hexkncdiaO\_ " \_\_'d\_-l-all~-! ester and introduced into the peptide chain by tz-catboxy-group

Synthesis of 6,5-fused bicyclic lactams
✍ Rudolf Mueller; Laszlo Revesz 📂 Article 📅 1994 🏛 Elsevier Science 🌐 French ⚖ 171 KB

The flmt short syntheds of the @eptIde mimetic (3s. 8S. SS)-8-amlnc-6-oxctndotiridiW-cafhoxyfk add 1 and its zpmtected dedvatlve 9 is described, empkyfng the Schoallkcpf bkkctim-ether methodokgy, folkwed by a highly specific lntramokcufar reductive afnfnatkn and spontaneous kctamizatlon. These W-fus

Synthesis of an azabicycloalkane amino a
✍ Régis Millet; Juozas Domarkas; Pauline Rombaux; Benoı̂t Rigo; Raymond Houssin; J 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 67 KB

Short syntheses are presented of the pseudo-dipeptide (3S,6S)-6-[(benzyloxy)carbonyl]amino-5-oxo-1,2,3,5,6,7-hexahydro-3-indolizinecarboxylic acid (1a) and of its (3S,6R) diastereoisomer (1b). The key step involves adding vinylogous b-enaminoester derived from pyroglutamic acid on an acrylate deriva

Pitfalls in the synthesis and biological
✍ Gerhard Kretzschmar; Alexander Toepfer; Christoph Hüls; Manfred Krause 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 539 KB

The lower molecular weight analog 12 of sialyl Lewis x was prepared and effected equal binding affinity to E-and P-selectin compared to the parent tetrasaccharide. If 12 was prepared using acidic ion exchange resins, false positive test were produced, especially binding to P-selectin seemed to be co