Synthesis of Stable Carbohydrate Mimetics as Potential Glycotherapeutics
β Scribed by Maarten H. D. Postema; Jared L. Piper; Russell L. Betts
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 8 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Review: 69 refs.
In multivalent glycoligands including cluster glycosides, one type of sugar epitope is normally clustered. Such molecules have been valuable tools for investigation and inhibition of cell adhesion processes. They have, for example, served as in vitro antiadhesives in mannose-specific bacterial adhes
Design, Synthesis, and Biological Evaluation of Carbohydrate-Based Mimetics of cRGDFV. -Carbohydrate-based non-peptide mimetics such as (I), (II), and (III) of the potent cyclopeptide title antagonist of Ξ±vΞ²3 and . alpha.vΞ²5 integrins are synthesized and evaluated in cell adhesion assays. Only the c