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Synthesis of “Mixed Type” Oligosaccharide Mimetics Based on a Carbohydrate Scaffold

✍ Scribed by Anupama Patel; Thisbe K. Lindhorst

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
341 KB
Volume
2002
Category
Article
ISSN
1434-193X

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✦ Synopsis

In multivalent glycoligands including cluster glycosides, one type of sugar epitope is normally clustered. Such molecules have been valuable tools for investigation and inhibition of cell adhesion processes. They have, for example, served as in vitro antiadhesives in mannose-specific bacterial adhesion. Wild-type bacteria, however, utilize a number of different sugar epitopes for adhesion, involving bacterial lectins of different specificity. The synthesis of glycomimetics containing sugar derivatives from different sugar series is therefore of interest, with the eventual goal of providing multivalent glycoligands of a more complex type. The synthesis of novel

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