ChemInform Abstract: Design, Synthesis, and Biological Evaluation of Carbohydrate-Based Mimetics of cRGDFV.

✍ Scribed by K. C. NICOLAOU; J. I. TRUJILLO; K. CHIBALE

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 31 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199743239

✦ Synopsis

Design, Synthesis, and Biological Evaluation of Carbohydrate-Based Mimetics of cRGDFV. -Carbohydrate-based non-peptide mimetics such as (I), (II), and (III) of the potent cyclopeptide title antagonist of αvβ3 and . alpha.vβ5 integrins are synthesized and evaluated in cell adhesion assays. Only the compound (III) shows a small inhibition of cell adhesion mediated by αIIbβ3. -(NICOLAOU, K. C.; TRUJILLO,