✦ LIBER ✦

Pitfalls in the synthesis and biological evaluation of sialyl-LewisX mimetics as potential selectin antagonists

✍ Scribed by Gerhard Kretzschmar; Alexander Toepfer; Christoph Hüls; Manfred Krause

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 539 KB
Volume: 53
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(96)01178-7

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✦ Synopsis

The lower molecular weight analog 12 of sialyl Lewis x was prepared and effected equal binding affinity to E-and P-selectin compared to the parent tetrasaccharide. If 12 was prepared using acidic ion exchange resins, false positive test were produced, especially binding to P-selectin seemed to be considerably enhanced. Traces of polyanions released from the resins which are difficult to detect by routine analysis were identified to be highly potent selectin inhibitors, probably by their action on a non-carbohydrate binding site.

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