✦ LIBER ✦

The Gabriel-Colman rearrangement in biological systems: design, synthesis and biological evaluation of phthalimide and saccharin derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3

✍ Scribed by William C. Groutas; Lee S. Chong; Radhika Venkataraman; Jeffrey B. Epp; Rongze Kuang; Nadene Houser-Archield; John R. Hoidal

Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 574 KB
Volume: 3
Category: Article
ISSN: 0968-0896
DOI: 10.1016/0968-0896(95)00013-7

No coin nor oath required. For personal study only.

✦ Synopsis

Almtraet--The results of a structure-activity relationship study focusing on the interaction of a series of phthalimide and saccharin derivatives with leukocyte elastase, cathepsin G and proteinase 3 are described. The phthalimide derivatives were found to be inactive while some of the saccharin derivatives were found to be fair inhibitors of these enzymes.

📜 SIMILAR VOLUMES

Design, synthesis and biological evaluat

Design, synthesis and biological evaluation of succinimide derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3

✍ William C. Groutas; Michael J. Brubaker; Lee S. Chong; Radhika Venkataraman; He 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 572 KB

Structure-activity relationship study and in vitro biochemical studies with human leukocyte elastase, cathepsin G and proteinase 3 were conducted using a series of succinimide derivatives.