Diastereoselective synthesis of a key in
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Takaji Matsumoto; Toshiyuki Murayama; Shigeru Mitsuhashi; Takashi Miura
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Article
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1999
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Elsevier Science
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French
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Asymmetric synthesis of (S)-5 has been accomplished with an excellent enantiomeric excess by hydrogenation of raeemie 5 using ruthenium-BINAP-diamine-KOH system, followed by oxidation. Magnesium enolate of (2S)-2-methoxycyclohexanone [(S)-5] reacts with the 4-aeetoxyazetidinone 4 to give the key int