Two guanine nucleotide analogs, 8(6aminohexyl)-amino-guanosine-5'-triphosphate and 8(6-aminohexyl)-amino-guanosine-5'-diphosphate, were synthesized from the monophosphate by phosphorylation with pyrophosphate or orthophosphate. Structural assignments were made according to nuclear magnetic resonance
β¦ LIBER β¦
The synthesis of 8-(6-aminohexyl)-amino-GMP and its applications as a general ligand in affinity chromatography
β Scribed by Peter E. Brodelius; Robert A. Lannom; Nathan O. Kaplan
- Book ID
- 115703822
- Publisher
- Elsevier Science
- Year
- 1978
- Tongue
- English
- Weight
- 560 KB
- Volume
- 188
- Category
- Article
- ISSN
- 0003-9861
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## Abstract The synthesis of a high affinity mannose receptor ligand, appropriately functionalized for chemoselective ligation with an antigen or DNAβbinding moieties is described. By a combination of solidβ and solutionβphase chemistry a versatile synthesis of the target structure was accomplished