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Synthesis of a functionalized high affinity mannose receptor ligand and its application in the construction of peptide-, polyamide- and PNA-conjugates

✍ Scribed by Olaf Kinzel; Daniela Fattori; Paolo Ingallinella; Elisabetta Bianchi; Dr Antonello Pessi

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 213 KB
Volume: 9
Category: Article
ISSN: 1075-2617
DOI: 10.1002/psc.463

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✦ Synopsis

Abstract

The synthesis of a high affinity mannose receptor ligand, appropriately functionalized for chemoselective ligation with an antigen or DNA‐binding moieties is described. By a combination of solid‐ and solution‐phase chemistry a versatile synthesis of the target structure was accomplished. Examples of subsequent ligation reactions are described. Copyright © 2003 European Peptide Society and John Wiley & Sons, Ltd.

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