The synthesis of 4-amino-3-(2-pyridyl)pyrazolo[5,1-c][1,2,4]triazine and some of its derivatives
✍ Scribed by Petr Cankař; Jan Slouka
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2003
- Tongue
- English
- Weight
- 40 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0022-152X
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✦ Synopsis
Abstract
A mixture of both geometrical isomers of hydrazones 3a‐3e was obtained by the coupling reactions of pyrazole‐3‐diazonium salts 2a‐2d and benzenediazonium chloride 2e with 2‐pyridylacetonitrile 1. Hydrazones 3a‐3d were cyclized to the corresponding 4‐amino‐3‐(2‐pyridyl)pyrazolo[5,1‐c][1,2,4]triazines 4a‐4d.
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## Abstract Some novel 3,7‐dimethyl‐6__H__‐pyrazolo[5,1‐c][1,2,4]triazin‐4‐ones were prepared **(3a‐g)**. Compounds **3a,b** were treated with hydrazines to afford various products **7a,b, 8a,b, 9 and lla,b** depending on the type of hydrazine derivative and reaction conditions. The benzoyloxyimino
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