𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The synthesis of 3-methyl-2-[4-14C]thiohydantoin a pharmacologically active metabolite of the antithyroid drug methimazole

✍ Scribed by Hugh T. Hood; Graham G. Skellern

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
143 KB
Volume
19
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Under basic conditions [^14^C]glycine reacts with methyl isothiocyanate producing 5‐methylthiohydantoic acid which cyclises at acidic pH to 3‐methyl‐2‐[4‐^14^C]thiohydantoin.

📜 SIMILAR VOLUMES

The synthesis of (−)-4-methyl-8-chloro-t
The synthesis of (−)-4-methyl-8-chloro-trans-1,2,3,4,4a,5,6,10b-octahydrobenzo-[f]-quinolin-3-one-[3-14C] (LY300502-14C]) via a circuitous route
✍ Fengjiun Kuo; William J. Wheeler 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 340 KB 👁 1 views

## Abstract The synthesis of the C‐14 labeled isotopomer of LY300502, a potent 5α‐reductase inhibitor has been accomplished in four radiochemical steps. The route involves the synthesis of LY300502‐[^14^C] from LY300502 __via__ a circuitous route; the label was introduced with ethyl chloroformate‐[

Synthesis of 14C-labeled 4-hydroxyindole
Synthesis of 14C-labeled 4-hydroxyindole as an intermediate for the preparation of (S)-2-[4-[2-[3-(indol-2-[14C]-4-yloxy)-2-hydroxypropylamino]-2-methylpropyl]-phenoxy]pyridine-5-carboxamide (LY368842-[indole-14C]) glycolate
✍ Boris A. Czeskis; Dean K. Clodfelter; William J. Wheeler 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 102 KB 👁 1 views

## Abstract Synthesis of 4‐hydroxyindole labeled with ^14^C at the 2‐position was accomplished based on the vicarious nucleophilic substitution reaction of benzyl‐protected 3‐nitrophenol with __p__‐chlorophenoxyacetonitrile‐[1‐^14^C]. This was followed by the reductive cyclization of __o__‐nitrocya

The synthesis of 7-chloro-1-methyl-5-phe
The synthesis of 7-chloro-1-methyl-5-phenyl-1, 3-dihydro-2H-1,4-benzodiazepin-2-one-5-14C and 7-nitro-1-methyl-5-(2′-fluorophenyl)-1, 3-dihydro-2H-1,4-benzodiazepin-2-one-5-14C
✍ H. H. Kaegi; W. Burger; C. J. Bader 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 French ⚖ 393 KB 👁 1 views

## Abstract Two benzodiazepines, Diazepam and Flunitrazepam, labeled with carbon‐14 in position 5 of the diazepine ring have been synthesized. Use of a condensation between iminochlorides and ^14^C‐benzonitriles, followed by exhaustive methylation of the resulting quinazolines and hydrolyses is des

Synthesis of the anti-tumor agent CI-973
Synthesis of the anti-tumor agent CI-973 {[SP-4-3-(R)]-[1,1-cyclobutanedicarboxylato(2)](2-methyl-1,4-[4-14C]butanediamine-N,N′)platinum}
✍ I. Victor Ekhato; James D. Hoeschele; Che C. Huang; Bela Nanavaty; Helen T. Lee 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 French ⚖ 307 KB 👁 1 views

## Abstract Starting from the chiral compound 1, (R)‐(+)‐2‐methyl‐1,4‐[^14^C]butanediamine 7 was synthesized in a sequence of reactions in which ^14^C‐label was introduce using label potassium cyanide. Compound 7 was reacted with potassium tetraiodoplatinate and silver 1,1‐cyclobutanedicarboxylate