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The synthesis of (−)-4-methyl-8-chloro-trans-1,2,3,4,4a,5,6,10b-octahydrobenzo-[f]-quinolin-3-one-[3-14C] (LY300502-14C]) via a circuitous route

✍ Scribed by Fengjiun Kuo; William J. Wheeler

Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
340 KB
Volume
34
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of the C‐14 labeled isotopomer of LY300502, a potent 5α‐reductase inhibitor has been accomplished in four radiochemical steps. The route involves the synthesis of LY300502‐[^14^C] from LY300502 via a circuitous route; the label was introduced with ethyl chloroformate‐[carbonyl‐^14^C].

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