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The synthesis of 1,3,4-thiadiazol-2-ylcyanamide sodium, a potentially useful anti-influenza agent and its [5-14C] and [UL-13C3] isotopomers

✍ Scribed by William J. Wheeler; William B. Blanchard

Publisher
John Wiley and Sons
Year
1992
Tongue
French
Weight
493 KB
Volume
31
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

As an aid to the study of the metabolism and disposition of LY217896 in laboratory animals and humans, ^14^C‐labeled material was prepared utilizing formic‐[^14^C] acid as the starting material. Uniformly labeled LY217896‐[^13^C] was also synthesized for use in metabolite identification. Formic acid, cyanogen bromide, and potassium cyanide which were >99% isotopically enriched with ^13^C were utilized; once the appropriate starting materials were synthesized, the synthesis of the ^13^C and ^14^C‐labeled materials were parallel.

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