The synthesis of (+)-11-epi-PGF2α and (−)-11-epi-PGE2
✍ Scribed by David M. Floyd; Guy A. Crosby; Ned M. Weinshenker
- Publisher
- Elsevier Science
- Year
- 1972
- Tongue
- French
- Weight
- 189 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
received in BX for publication 3 JUQ lr(~l The Corey synthesis1 . is especially well suited for the preparation of prostaglandin stereoisomers and provides the opportunity to establish structure-activity correlations for this unique class of naturally occurring substances. By suitable
📜 SIMILAR VOLUMES
The inversion of configuration at C-4 (C-11 in prostaglandin numbering) performed either on the resolved (-)1( ?-hydroxy-.%a-methoxvmethvl-cvclonent-2-en-1 B -acetic acid (I), by-product of Co\_ rey synthesis of natural prostnclandins 1 or on its related Derivatives makes them suitable inteE
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
## Smmary: A facile 1,5-migration of a t-butyldimethylsilyl group and a new cleavage reaction of t-butyldimethylsilyl ether to alcohol in prostaglandin intermediates are described.
The first total synthesis of ent-15(RS)-2,3-dinor-5,6-dihydro-8-epi-PGF2c~ 1 is described using diacetone-D-glucose as starting material. The major urinary metabolite of the isoprostane 8-epi-PGF2ct is 2,3-dinor-5,6-dihydro-8-epi-PGF2c~, which is a potent lipid peroxidation index to obtain an integr