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Total synthesis of ent-15(RS)-2,3-dinor-5,6-dihydro-8-epi-PGF2α

✍ Scribed by Alexandre Guy; Thierry Durand; Arlene Roland; Emmanuelle Cormenier; Jean-Claude Rossi

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
247 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

The first total synthesis of ent-15(RS)-2,3-dinor-5,6-dihydro-8-epi-PGF2c~ 1 is described using diacetone-D-glucose as starting material. The major urinary metabolite of the isoprostane 8-epi-PGF2ct is 2,3-dinor-5,6-dihydro-8-epi-PGF2c~, which is a potent lipid peroxidation index to obtain an integrated assessment of oxidative stress in humans.

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