✍ Scribed by Janez Smodiš; Branko Stanovnik
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A convenient synthesis of substituted 2-hydroxy-3-dimethylaminopropenoates is reported. They react with cyclic 1,3-diketones, with aromatic and heteroaromatic hydroxy compounds to afford the corresponding 3-substituted hydroxytetrahydro-2H-l-benzopyran-2-ones, benzo-and naphthopyran-2-ones and azolo-and azinopyran-2-ones. respectively. Catalytic debenzylation of 3-benzyloxy substituted fused pyran-2-ones gives free 3-hydroxy derivatives.
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## Abstract Alkyl (Z)‐2‐[(__E__)‐2‐ethoxycarbonyl‐2‐(2‐pyridinyl)ethenyl]amino‐3‐dimethylaminopropenoates **7** and **8** were prepared from ethyl 2‐pyridinylacetate (1) in two steps. Substitution of the dimethylamino group with alkyl‐, aryl‐, or heteroarylamines afforded the corresponding β‐alkyl‐
Synthesis and Properties of 2-Substituted 4-Hydroxy-4-isoxazoline-3ones. -The synthesis of hitherto not described 2-substituted 4-hydroxyisoxazolinones (IV) via intramolecular cyclization of generally unstable bromopyruvohydroxamic acids (III) is accomplished. The novel heterocycles display moderat