The synthesis and study of side-chain lactam-bridged peptides
โ Scribed by John W. Taylor
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2002
- Tongue
- English
- Weight
- 971 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0006-3525
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## Abstract Aibโrich sideโchain lactamโbridged oligomers Acโ($\rm{G{\overline{lu-Aib-Aib-Ly}s}}$)~__n__~โAlaโOH with __n__ = 1,2,3 were designed and synthesized as putative models of the 3~10~โhelix. The lactam bridge between the side chains of LโGlu and LโLys in (i) โ (i + 3) positions was introdu
Conditions for the synthesis of i -(i +4) side chain-to-side chain head-to-tail Lys Glu and Glu Lys linked cyclic peptides related to hypoglycaemic analogues of human growth hormone hGH [6-13] have been examined. The success of the cyclisation reaction with the corresponding resin-bound, partially p
## Abstract The effect of charged side chains on the ionization and fluorescence of the Tyr^4^ phenolic group in angiotensin (AspโArgโValโTyrโIleโHisโProโPhe) was investigated. Several synthetic peptides related to angiotensin were titrated spectrophotometrically and quantum yields of tyrosine fluo