Synthesis and conformational study of peptides possessing helically arranged ΔZPhe side chains
✍ Scribed by Yoshihito Inai; Takaaki Ito; Tadamichi Hirabayashi; Kenji Yokota
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1993
- Tongue
- English
- Weight
- 880 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0006-3525
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Using the host-guest technique, tentative scales for the helix-inducing power and the (3-structure-forming potential of various side-chain protected amino acid residues in trifluoroethanol are established mainly by CD measurements. The generally lower tendency for (3-structure formation of the host-
## Abstract Conformational studies of the peptides constructed from achiral amino acid residues Aib and Δ^Z^Phe (I) Ac‐Aib‐Δ^Z^Phe‐NHMe (II), and Ac‐(Aib‐Δ^Z^Phe)~3~‐NHMe; peptides III–VI having L‐Leu or D‐Leu at either the N‐ or the C‐terminal position and of peptides VII–X having Leu residues in