The synthesis and reactivity of optically pure amino acids bearing side-chain thioamides
✍ Scribed by Sanderson, John M.; Singh, P.; Fishwick, Colin W. G.; Findlay, John B. C.
- Book ID
- 120580305
- Publisher
- Royal Society of Chemistry
- Year
- 2000
- Weight
- 115 KB
- Volume
- 19
- Category
- Article
- ISSN
- 1472-7781
- DOI
- 10.1039/B004688O
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📜 SIMILAR VOLUMES
The highly efficient preparation of two optically pure phenylalanine analogues containing p-N-aryl thiobenzamide moieties are described. These amino acids are readily incorporated into peptides via standard solid-phase strategies.
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## Abstract A straightforward synthesis of 2,6‐disubstituted piperidines bearing α‐amino acid side‐chains was developed. Synthesis was based on a Horner−Wadsworth−Emmons condensation of a β‐ketophosphonate derived from an α‐amino acid residue with a β‐homologated aldehyde of an __N__‐protected amin
Two Novel Amino Acid Derivatives Containing Side-Chain Thioamides for the Synthesis of Photoactivatable Peptides. -An efficient method to obtain novel amino acid derivatives (V), which can be introduced into peptides by solid-phase standard procedures, is described. -