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The synthesis and purification of 8-14C-theophylline

✍ Scribed by Suzanne M. Lohmann; Ralph P. Miech

Publisher
John Wiley and Sons
Year
1975
Tongue
French
Weight
181 KB
Volume
11
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The enzymes responsible for the metabolism of methylated xanthines suah as theophylline, theobromine, and caffeine have until now escaped identification (1, 2). However, a sensitive radiometric method of analysis of theophylline metabolism (3) was made possible by the synthesis and purification of 8‐^14^C‐theophylline (^14^C‐Theo). ^14^C‐Theo was synthesized by the incorporation of ^14^C from ^14^C‐formic acid into the 8‐position of the purine ring. Purification of the ^14^C‐Theo was accomplished by subjecting the crude produot to cation‐exchange column chromatography with AG50W‐X12, 50–100 mesh resin of the hydrogen ion form.

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