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The Synthesis and Inhibitory Activity of Dethiotrypanothione and Analogues against Trypanothione Reductase

โœ Scribed by Czechowicz, Josephine A.; Wilhelm, April K.; Spalding, Maroya D.; Larson, Anna M.; Engel, Linnea K.; Alberg, David G.


Book ID
126394131
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
93 KB
Volume
72
Category
Article
ISSN
0022-3263

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## Dedicated to Professor Dieter Seebach on the occasion of his 65th birthday Gelastatin A and B, isolated from culture broth of Westerdykella multispora F 50733, have been reported to exhibit MMP-inhibitory activities at a sub-micromolar level. In an effort to exploit this lead, we synthesized ge