Synthesis and evaluation of substrate analogue inhibitors of trypanothione reductase
β Scribed by Duyzend, Michael H.; Clark, Christopher T.; Simmons, Shayna L.; Johnson, Wade B.; Larson, Anna M.; Leconte, Aaron M.; Wills, Andrew W.; Ginder-Vogel, Matthew; Wilhelm, April K.; Czechowicz, Josephine A.; Alberg, David G.
- Book ID
- 115531593
- Publisher
- Informa plc
- Year
- 2011
- Tongue
- English
- Weight
- 971 KB
- Volume
- 27
- Category
- Article
- ISSN
- 1475-6366
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## Abstract __Thirty two analogues of phencyclidine were synthesised and tested as inhibitors of trypanothione reductase (TryR), a potential drug target in trypanosome and leishmania parasites. The lead compound BTCP (**1**, 1β(1βbenzo[__b__]thiophenβ2βylβcyclohexyl) piperidine) was found to be a c