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Improved Inhibitors of Trypanothione Reductase by Combination of Motifs: Synthesis, Inhibitory Potency, Binding Mode, and Antiprotozoal Activities

✍ Scribed by Christian Eberle; Birgit Sophia Lauber; Daniel Fankhauser; Marcel Kaiser; Prof. Dr. Reto Brun; Prof. Dr. R. Luise Krauth-Siegel; Prof. Dr. François Diederich

Book ID: 102804356
Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 535 KB
Volume: 6
Category: Article
ISSN: 1860-7179
DOI: 10.1002/cmdc.201000420

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The inside cover picture shows a modeled structure of a novel competitive inhibitor of trypanothione reductase (TR) in the active site of the enzyme. TR is unique to trypanosomatid parasites and a target for lead discovery programs. The parasites depicted show the high accumulation of the fluorescen