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Synthesis, Inhibition Potency, Binding Mode, and Antiprotozoal Activities of Fluorescent Inhibitors of Trypanothione Reductase Based on Mepacrine-Conjugated Diaryl Sulfide Scaffolds

✍ Scribed by Christian Eberle; Johannes A. Burkhard; Bernhard Stump; Marcel Kaiser; Reto Brun; R. Luise Krauth-Siegel; François Diederich


Book ID
102806158
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
555 KB
Volume
4
Category
Article
ISSN
1860-7179

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Inside Cover: Synthesis, Inhibition Pote
✍ Christian Eberle; Johannes A. Burkhard; Bernhard Stump; Marcel Kaiser; Reto Brun 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 467 KB

The inside cover picture shows a modeled structure of a novel competitive inhibitor of trypanothione reductase (TR) in the active site of the enzyme. TR is unique to trypanosomatid parasites and a target for lead discovery programs. The parasites depicted show the high accumulation of the fluorescen