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Diaryl sulfide-based inhibitors of trypanothione reductase: inhibition potency, revised binding mode and antiprotozoal activities

✍ Scribed by Stump, Bernhard; Eberle, Christian; Kaiser, Marcel; Brun, Reto; Krauth-Siegel, R. Luise; Diederich, François


Book ID
118278309
Publisher
Royal Society of Chemistry
Year
2008
Tongue
English
Weight
491 KB
Volume
6
Category
Article
ISSN
1477-0520

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Inside Cover: Synthesis, Inhibition Pote
✍ Christian Eberle; Johannes A. Burkhard; Bernhard Stump; Marcel Kaiser; Reto Brun 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 467 KB

The inside cover picture shows a modeled structure of a novel competitive inhibitor of trypanothione reductase (TR) in the active site of the enzyme. TR is unique to trypanosomatid parasites and a target for lead discovery programs. The parasites depicted show the high accumulation of the fluorescen